Based from a study in the field of gastroenterology, healthy adults who are taking proton pump inhibitors for almost eight weeks will induce acid-related problems such as acid regurgitation, heartburn, and dyspepsia once the intake of medication is ceased or discontinued.

According to researchers, they have found out those healthy individuals or those who do not experience heartburn and other acid-related problems are experiencing such symptoms after an eight weeks intake of proton pump inhibitors and ceasing it after.

Because of these results, researchers are led to believe that withdrawal related to prolonged intake of proton pump inhibitors may result to acid rebound which causes the manifestation of symptoms related to increased acidity.

It is very apparent that proton pump inhibitors are widely used for the treatment of acid related disorders. The incidence of patients being treated through intake of proton pump inhibitors is currently stable but the use of it as a prolonged treatment is becoming more extensive and increasing rapidly. The data gathered by researchers showed that patients who were prescribed with proton pump inhibitors for treatment of acid related conditions continue to use the medication for long term even though it is not intended for long term therapy.

The results of the mentioned study show that those who were taking proton pump inhibitors for a long period of time and suddenly ceased intake tend to develop rebound effects such as rebound hyperacidity. Rebound hyperacidity is defined as the increase in the gastric secretion of acid wherein the levels are much higher than the levels before the treatment regimen.

Based from the data, the symptoms that were observed on the subjects were ranging from mild to moderate discomforts. These discomforts would include stomach pains, heartburn, acid regurgitation, and dyspepsia.

The study had 120 subjects who took proton pump inhibitors for eight weeks followed by a placebo for four weeks. Subjects displayed different acid related symptoms but one thing is clear. The subjects developed the symptoms right after the cessation of the medication which strongly indicates that prolonged intake of proton pump inhibitors can cause rebound hyperacidity.

Experts concluded that dependence to proton pump inhibitors can cause rebound effects which can aggravate the hyperacidity problem of the patient. It is also the rebound hyperacidity which can cause the symptoms related to acidity such as heartburn, dyspepsia, and acid regurgitation. Experts have also rooted the main cause why the prolonged usage of proton pump inhibitors are continuously increasing is because of the dependence to proton pump inhibitors.